Association Between Thiopurine Use And Nonmelanoma Skin Cancers In Patients With Inflammatory Bowel Disease: A Meta-analysis

METHODS: We searched electronic databases for full journal articles reporting on the risk of developing NMSC in patients with IBD on thiopurine and hand searched the reference lists of all retrieved articles. Pooled adjusted hazard ratios and 95% confidence intervals (CIs) were determined using a random-effects model. Publication bias was assessed using Funnel plots and Egger’s test. Heterogeneity was assessed using Cochran’s Q and the I2 statistic. RESULTS: Eight studies involving 60,351 patients provided data on the risk of developing NMSC in patients with IBD on thiopurines. The pooled adjusted hazards ratio of developing NMSC after exposure to thiopurines in patients with IBD was 2.28 (95% CI: 1.50 to 3.45). There was significant heterogeneity (I2=76%) between the studies but no evidence of publication bias. Meta regression analysis suggested that the population studied (hospital-based vs. population-based) and duration of follow-up contributed significantly to heterogeneity. Grouping studies based on population studied and duration showed higher hazard rations in hospital-based and shorter duration studies. CONCLUSIONS: The risk of developing NMSC in patients with IBD on thiopurines is only modestly elevated.

navigate to this site http://www.nature.com/ajg/journal/vaop/ncurrent/abs/ajg2013451a.html

Gabriel Lee, M.D., Joins Houston-Bay Area Gastroenterology

Ravi S. Mani , Dr. Nikhil Inamdar , Dr. Syed Jafri, Dr. Sezen Altug , Dr. Manish Rungta and Dr. Naveen Surapaneni . Dr. Lee obtained his medical degree from Baylor College of Medicine in Houston and completeda residency in Internal Medicine at the University of Texas Medical Branch in Galveston, before entering his fellowship programs in Galveston and Advanced training in San Antonio, Texas.He has native fluency in Spanish. Dr. Lee and his gastroenterology colleagues are part of Bay Area Gastroenterology in Clear Lake, which was the first Houston gastroenterology and endoscopy practice to offer office-based accredited Virtual colonoscopy screening .Specializing in the diagnosis and treatment of ailments of the stomach, intestines, colon, liver, gallbladder and pancreas, the group has offices in Clear Lake, Houston and Pearland. The group also offers virtual colonoscopy onsite at their accredited Imaging Center, in addition to onsite endoscopic procedures, colonoscopy and upper endoscopy at the Bay Area Houston Endoscopy Center. Contact Bay Area Gastroenterology at http://www.Gibay.com to schedule a consult. Or call 281-480-6264 for more information.

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